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Professor
Tel: (530) 754-9577
Fax: (530) 754-6915
Email: gervay@chem.ucdavis.edu
Office Location: Chemistry Annex 5463
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Professor Gervay-Hague was named an Eli Lilly Grantee in 1997 and was appointed a Sloan Fellow in 1998. In 1999, She was awarded the Horace S. Isbell Prize by the Carbohydrate Division of the American Chemical Society, and she was also the recipient of the GenCorp Technology Achievement Award. Organic Synthesis and Chemical BiologyResearch Interests: Organic synthesis, Chemical biology, carbohydrate chemistry, HIV, cancer, molecular scaffolds, polyvalent display, protein/carbohydrate interactions, enzyme inhibition. The Gervay-Hague research group has established an Internationally recognized program in the area of carbohydrate chemistry directed toward the design and synthesis of chemotherapeutics targeting HIV infection and cancer. Although the disease states differ, our method of lead discovery has consistently involved understanding disease processes at a molecular level so that rational drug design can be implemented. This approach has led to studies at the interface of chemistry, biology, and virology. Our work is characterized by a total approach to drug design and synthesis that utilizes a wide variety of experimental tools available to chemists and biologists. The synthesis of alpha-galactosyl ceramide natural products is a core area of investigation in the Gervay-Hague lab. These natural products were originally isolated from marine sponge, and quantities for biological studies were scarce. One-pot synthetic routes for large quantity production of alpha-galactosyl ceramides using glycosyl iodide chemistry have been developed. Our laboratory is a leader in developing these methods, which exploit the unique reactivity of glycosyl iodides providing highly efficient routes to important synthetic precursors for natural product synthesis and combinatorial library construction. [Project 1 ] A second key area of investigation includes the use of sulfones as neutral phosphate isosteres. We have recently reported detailed studies of a new class of HIV-integrase inhibitors having a geminal-disulfone functionality with potent antiviral selectivity. Computational studies suggest that two major modes of binding are likely and that the disulfone analogs bind similarly to previously identified HIV-IN inhibitors currently in clinical trials. A compound capable of direct inactivation of HIV has also been identified. [Project 2 ] Finally, we have begun a new area of investigation focused on developing methods for the efficient conjugation of site-specific functionalized proteins that are used for cancer chemotherapeutics. In an effort to improve avidity, singly functionalized scFv proteins directed against the MUC-1 antigen have been successfully dimerized using a 1-3 dipolar cyclization strategy. Our central contributions involve introduction of a trialkyne functionality onto rigid scaffolds that promote the cyclization process. [Project 3 ] 1990-1992 NIH Post-Doctoral Fellow, Department of Chemistry, Yale University, Professor Samuel J. Danishefsky 1992-1998 Assistant Professor, Department of Chemistry, The University of Arizona 1998-2001 Associate Professor, Department of Chemistry, The University of Arizona 2000-2001 On-Site Consultant, Internal Disease Unit, Roche Bioscience, 3401 Hillview Ave., Palo Alto, CA (Sabbatical Leave) 2001-present Professor, Department of Chemistry, University of California, Davis
Protein Kinase Cd is a Critical Regulator of CD1d-Mediated
Antigen Presentation. R.R. Brutkiewicz, C.A. Willard, K.K.
Gillett-Heacock, M.R. Pawlak, J.C. Bailey, M.A. Khan, M. Nagala, W. Du,
J. Gervay-Hague, and G.J. Renukaradhya. Eur. J. Immun.,
2007, 37, 2390-2395.
Synthesis of C-4 and C-7 Triazole Analogs of Zanamivir as
Multivalent Sialic Acid Containing Scaffolds. Y. Lu, and J.
Gervay-Hague. Carb. Res., 2007, 342,
1636-1650.
A Diisopropoxyphosphonate Disulfone. J.H.W. Wong, M.M. Olmstead, J.C. Fettinger, and J. Gervay-Hague. Acta Cryst. Sec. E., 2007, 63, 3046. A Diisopropoxyphosphonate Monosulfone. J.H.W. Wong, M.M. Olmstead, and J. Gervay-Hague. Acta Cryst. Sec. E., 2007, 63, 3045.
Mechanistic
Studies on the Stereoselective Formation of beta-Mannosides from
Mannosyl Iodides Using alpha-Deuterium Kinetic Isotope Effects. M.H.
El-Badri, D. Willenbring, D.J. Tantillo, and J. Gervay-Hague.
J. Org. Chem.,
2007,
72,
4663-4672.
Efficient, One-Pot Synthesis of Biologically Active
alpha-Linked Glycolipids. W. Du, S.S. Kulkarni, and J.
Gervay-Hague. Chem. Commun., 2007, 23,
2336-2338.
Direct Inactivation of Human Immunodeficiency Virus Type 1
by a Novel Small-Molecule Entry Inhibitor, DCM205. Y.T. Duong, D.C.
Meadows, I.K. Srivastava, J. Gervay-Hague, and T.W. North.
Antimicrob. Agent Chemother., 2007, 51, 1780-1786.
Chemotherapeutic Interventions Targeting HIV Interactions with Host-Associated Carbohydrates. K.D. McReynolds, and J. Gervay-Hague. Chem. Rev., 2007, 107, 1533-1552. A Role for Natural Killer T Cells and CD1d Molecules in Counteracting Suppression of Hematopoiesis in Mice Induced by Infection with Murine Cytomegalovirus. H.E. Broxmeyer, A. Dent, S. Cooper, G. Hangoc, Z.-Y. Wang, W. Du, J. Gervay-Hague, V. Sriram, G.J. Renukaradhya, and R.R. Brutkiewicz. Exper. Hematology, 2007, 35, 87-93. Construction of di-scFv Through a Trivalent Alkyne-Azide 1,3-Dipolar Cycloaddition. A. Natarajan, W. Du, C. Xiong, G.L. DeNardo, S.J. DeNardo and J. Gervay-Hague. Chem. Commun., 2007, 695-697. Ring Substituent Effects on Biological Activity of Vinyl Sulfones as Inhibitors of HIV-1. D.C. Meadows, and J. Gervay-Hague. Bioorg. Med. Chem., 2007, 15, 1127-1137. Efficient Synthesis of a C-Analogue of the Immunogenic Bacterial Glycolipid BbGl2. S.S. Kulkarni, and J. Gervay-Hague. Org. Lett., 2006, 8, 5765-5768. Inhibition of CD1d1-mediated Antigen Presentation by the Vaccinia Virus B1R and H5R Molecules. T.J.R. Webb, R.A. Litavecz, M.A. Khan, W. Du, J. Gervay-Hague, G.J. Renukaradhya, and R.R. Brutkiewicz. Euro. J. Immunol., 2006, 36, 2595-2600. Vinyl Sulfones: Synthetic Preparations and Medicinal Chemistry Applications. D.C. Meadows, and J. Gervay-Hague. Med. Chem. Rev., 2006, 26, 793-814. Correlation of Biological Activity with Active Site Binding Modes of Geminal Disulfone HIV-1 Integrase Inhibitors. D.C. Meadows, D.J. Tantillo, and J. Gervay-Hague. ChemMedChem, 2006, 1, 959-964. CD44 Differentially Activates Mouse NK T Cells and Conventional T Cells. J. Larkin, G.J. Renukaradhya, V. Sriram, W. Du, J. Gervay-Hague, and R.R. Brutkiewicz. J. Immunol., 2006, 177, 268-279. Inhibition of Antitumor Immunity by Invariant Natural Killer T Cells in a T-Cell Lymphoma Model in Vivo. G.J. Renukaradhya, V. Sriram, W. Du, J. Gervay-Hague, L. Van Kaer, and R.R. Brutkiewicz. Int. J. Cancer, 2006, 118, 3045-3053. Current Developments in HIV Chemotherapy. D.C. Meadows and J. Gervay-Hague. ChemMedChem, 2006, 1, 16-29. Polyvalent Interactions of HIV-gp120 Protein and Nanostructures of Carbohydrate Ligands. J.-J. Yu, B. Nolting, Y.H. Tan, X. Li, J. Gervay-Hague, and G.-y. Liu. NanoBiotechnology, 2005, 1, 201-210. Efficient Synthesis of Man2, Man3, and Man5 Oligosaccharides, Using Mannosyl Iodide Donors. S.N. Lam and J. Gervay-Hague. J. Org. Chem. 2005, 70, 8772-8779. Virus-Induced Inhibition of CD1d1-Mediated Antigen Presentation: Reciprocal Regulation by p38 and ERK. G.J. Renukaradhya, T.J.R. Webb, M.A. Khan, Y.L. Lin, W. Du, J. Gervay-Hague, and R.R. Brutkiewicz. J. Immunol., 2005, 175, 4301-4308. Thermal Effect in beta-Selective Glycosylation Reactions Using Glycosyl Iodides. M.H. El-Badry and J. Gervay-Hague. Tet. Lett. 2005, 46, 6727-6728. Cell Wall Glycophingolipids of Sphingomonas paucimobilis are CD1d-specific Ligands for NKT cells. V. Sriram, W. Du, J. Gervay-Hague, and R.R. Brutkiewicz. Eur. J. Immunol., 2005, 35, 1692-1701. Synthesis and Biological Evaluation of Geminal Disulfones as HIV-1 Integrase Inhibitors. D.C. Meadows, T.B. Mathews, T.W. North, M.J. Hadd, C.L. Kuo, N. Neamati, D.J. Tantillo, and J. Gervay-Hague. J. Med. Chem., 2005, 48, 4526-4534. Efficient Synthesis of alpha-Galactosyl Ceramide Analogues Using Glycosyl Iodide Donors. W. Du and J. Gervay-Hague. Org. Lett., 2005, 7, 2063-2065. One-Bead-One-Inhibitor-One-Substrate Screening of Neuraminidase Activity. L. Ying and J. Gervay-Hague. ChemBioChem, 2005, 6, 1857-1865. A Topologically Segregated One-Bead-One-Compound Combinatorial Glycopeptide Library for Identification of High-Affinity Lectin Ligands. L. Ying, R. Liu, J. Zhang, K. Lam, C.B. Lebrilla, and J. Gervay-Hague. J. Comb. Chem., 2005, 7, 372-384. Glycal Scavenging in the Synthesis of Disaccharides Using Mannosyl Iodide Donors. S.N. Lam and J. Gervay-Hague. J. Org. Chem., 2005, 70, 2387-2390. Unique Reactions of Glycosyl Iodides with Oxa- and Thiocycloalkane Acceptors. D. Dabideen and J. Gervay-Hague. Org. Lett., 2004, 6, 973-975. Synthesis of Oligomers Derived from Amide-Linked Neuraminic Acid Analogs. T.Q. Gregar and J. Gervay-Hague. J. Org. Chem., 2004, 69 1001-1009. Synthesis of N-(fluorine-9-ylmethoxycarbonyl)glycopyranosylamine Uronic Acids. L. Ying and J. Gervay-Hague. Carbohydr. Res., 2003, 339, 367-375. An Effcient Route to 2-Deoxy-beta-O-aryl-D-Glycosides via Direct Displacement of Glycosyl Iodides. S.N. Lam and J. Gervay-Hague. Org. Lett., 2003, 5, 4219-4222. Synthesis of Gold Glyconanoparticles and Biological Evaluation of Recombinant Gp120 Interactions. B. Nolting, J.-J. Yu, G.-y. Liu, S.-J. Cho, S. Kauzlarich and J. Gervay-Hague. Langmuir, 2003, 19, 6465-73. General Methods for the Synthesis of Glycopyranosyl Azide Uronic Acids. L. Ying and J. Gervay-Hague. Carbohydr. Res., 2003, 338, 835-41. Solution Phase Oligosaccharide Synthesis Using Glucosyl Iodides: A Comparative Study. S. Lam and J. Gervay-Hague. Carbohydr. Res., 2002, 337, 1953-65. Synthesis of Novel Glycolipids That Bind HIV-1 Gp120. R.Y. LaBell, N.E. Jacobsen, J. Gervay-Hague, and D.F. O’Brien. Bioconjugate Chem., 2002, 13, 143-149. Solution-Phase Hexasaccharide Synthesis Using Glucosyl Iodides. S.N. Lam and J. Gervay-Hague. Org. Lett., 2002, 4, 2039-2042. Non-natural Glycosphingolipids and Structurally Simpler Analogs Bind HIV-1 Recombinant Gp120. K.D. McReynolds, A. Bhat, J.C. Conboy, S.S. Saavedra, and J. Gervay-Hague. Bioorg. Med. Chem,. 2002, 1, 625-637. Quantitative Measurements of Recombinant HIV Surface Glycoprotein Gp120 Binding to Glycosphingolipids Expressed in Planar Supported Lipid Bilayers. J.C. Conboy, K.D. McReynolds, J. Gervay-Hague, and S.S. Saavedra. J. Am. Chem. Soc., 2002, 124, 968-977. Efficient Syntheses of beta-Cyanosugars Using Glycosyl Iodides Generated from Per-O-Silylated Mono- and Disaccharides. A. Bhat and J. Gervay-Hague. Org. Lett., 2001, 3, 2081-2084. A Novel Reagent for the Synthesis of Geminal Disulfones. M.J. Hadd, M.A. Smith, M.D. Carducci, J. Gervay-Hague. Tet. Lett., 2001, 42, 5137-5140. Pyranosyl Sugar Amino Acid Conjugates: Their Biological Origins, Synthetic Preparations, and Structural Characterization. J. Gervay-Hague, and T.M. Weathers, in Carolyn Bertozzi and George Wang, Editors, Glycochemistry Marcel Dekker Inc., New York 2001 Gp120 Binds Cooperatively to Several Biologically Relevant Glycosphingolipids: Quantitative Measurements at Equilibrium by Total Internal Reflection Fluorescence Microscopy. J.C. Conboy, K. D. McReynolds, J. Gervay-Hague, and S.S. Saavedra. Angew. Chem. Int. Engl. Ed., 2000, 39, 2882-2884. Examining the Secondary Structures of Unnatural Peptides and Carbohydrate-Based Compounds Utilizing Circular Dichroism. K.D. McReynolds and J. Gervay-Hague. Tetrahedron Asymmetry, 2000, 11, 337-362. Glycosyl Iodides Are Highly Efficient Donors Under Neutral Conditions. M.J. Hadd and J. Gervay. Carbohydr. Res., 1999, 320, 61-69. Synthesis of Biotinylated Glycoconjugates and Their Use in a Novel ELISA for Direct Comparison of HIV-1 Gp120 Recognition of GalCer and Related Carbohydrate analogs. K.D. McReynolds, M.J. Hadd, and J. Gervay-Hague. Bioconj. Chem., 1999, 10, 1021. Utilization of ELISA Technology to Measure Biological Activities of Relevant in Disease States. J. Gervay and K.D. McReynolds. Curr. Med. Chem., 1999, 6, 129-153. Monosaccharides: Their Chemistry and Their Roles in Natural Products. by P. Collins and R. Ferrier. Reviewed by J. Gervay. ChemTracts, 1998, 11, 310. The Chemistry of C-Glycosides. by D. E. Levy and C. Tang. Reviewed by J. Gervay and P.S. Ramamoorthy. ChemTracts, 1998, 11, 310. Carbohydrates in Drug Design. Reviewed by J. Gervay. Edited by Z.J. Witczak. J. Am. Chem. Soc., 1998, 120, 5604. Glycosyl Iodides in Organic Synthesis. J. Gervay, in Organic Synthesis Theory and Application, JAI Press Monograph Series, 1998, 4, 121-153. Solid Phase Synthesis and Secondary Structural Studies of (1-->5) Amide Linked Sialooligomers. L. Szabo, B.L. Smith, K.D. McReynolds, A.L. Parrill, E.R. Morris, and J. Gervay. J. Org. Chem., 1998, 63, 1074-1078. Perspectives from a Newly Begun Career. J. Gervay. J. Chem. Ed. 1998, 75, 1521. Solution Phase Synthesis of Amide Linked N-Acetyl Neuraminic Acid, alpha-Amino Acid, and Sugar Amino Acid Conjugates. P.S. Ramamoorthy and J. Gervay. J. Org. Chem., 1997, 62, 7801. Anionic Additions to Glycosyl Iodides: Highly Stereoselective Syntheses of beta C-, N-, and O-Glycosides. J. Gervay and M.J. Hadd. J. Org. Chem., 1997, 62, 6961. HI/Acetic Acid Reduction of Peracetylated N-Acetyl Neuraminic Acid Esters to Stereoselectively Provide alpha-2-Deoxy-2-hydrido Derivatives. J. Gervay and T.Q. Gregar. Tet. Lett., 1997, 38, 5921. Studies on the Synthesis of C-Glycoside Sulfones as Potential Glycosyl Transferase Inhibitors. J. Gervay, T.M. Flaherty, and D. Holmes. Tetrahedron, 1997, 53, 16355-16364. Ring Opening of Sialyllactones with Glycine Esters: Synthesis of Selectively Protected Glycinyl-NeuAc Saccharopeptides. J. Gervay, P.S. Ramamoorthy, and N.N. Mamuya. Tetrahedron, 1997, 53, 11039. Computational Studies of Siallyllactones: Methods and Uses. A.L. Parrill, N. Mamuya, D.P. Dolata, and J. Gervay. Glycoconj., 1997, 14, 523. Mechanistic Studies on the Stereoselective Synthesis of Glycosyl Iodides: First Characterization of beta-Glycosyl Iodides. J. Gervay, T. Nguyen, and M.J. Hadd. Carbohydr. Res., 1997, 300, 119. Synthesis of 13C Enriched Sialyllactones and Their Characterization Using Isotope Edited Inverse Detected NMR Spectroscopy. J. Gervay, N.N. Mamuya and R. A. Barber. Tet. Lett., 1997, 38, 1865. Solution Phase Synthesis of (1-->5)-Amide Linked Sugar Amino Acids Derived from Sialic Acids. J. Gervay, T.M. Flaherty, and C. Nguyen. Tet. Lett., 1997, 38, 1493. Temperature Dependence of Molecular Conformation, Dynamics, and Chemical Shift Anisotropy of alpha,alpha-Trehalose in D2O by NMR Relaxation. G. Batta, K.E. Kover, J. Gervay, M. Hornyak, and G.M. Roberts. J. Am. Chem. Soc., 1997, 119, 1336. Fostering Curiosity-Driven Learning Through Interactive Multimedia Representations of Biological Molecules. A.L. Parill and J. Gervay. J. Chem. Ed., 1997, 74, 1141. Discovery-Based Stereochemistry Tutorials Available on the World Wide Web. A.L. Parill and J. Gervay. J. Chem. Ed., 1997, 74, 329. The Stereochem Game: Making Chemistry More Fun. A.L. Parill and J. Gervay. Chemical Educator, 1996, 1, 5. Carbohydrate Building Blocks. Reviewed by J. Gervay. J. Am. Chem. Soc., 1996, 51, 9206. Hydride Addition to 1,2-Anhydrosugars: A Highly Stereoselective Route to Anhydroalditols. T.M. Flaherty and J. Gervay. Tet. Lett., 1996, 37, 961. 2D NMR Analysis of the Polylactone Derivative of Colominic Acid: Complete 1H and 13C NMR chemical shift assignments. T.M. Flaherty and J. Gervay. Carbohydr. Res., 1996, 281, 173. Solution-Phase 13C and 1H Chemical Shift Anisotropy of Sialic Acid and Its Homopolymer (Colominic Acid) from Cross-Correlated Relaxation. G. Batta and J. Gervay. J. Am. Chem. Soc., 1995, 117, 368. Application of Glycals to the Synthesis of Oligosaccharides: Convergent Total Syntheses of the Lewis X Trisaccharide Sialyl Lewis X Antigenic Determinant and Higher Congeners. S.J. Danishefsky, J. Gervay, J.M. Peterson, F.E. McDonald, K. Koseki; D.A. Griffith; T. Oriyama; and S.P. Marsden. J. Am. Chem. Soc., 1995, 117, 1940. pH Dependent C6 and C8 13C Chemical Shift Assignment in N-Acetyl Neuraminic Acid. J. Gervay and G. Batta. Tet. Lett., 1994, 35, 3009. Three Spin Effects in 1H-13C (Reverse) Heteronuclear NOE and INEPT-(R)HOESY Spectra of [1-13C]Methyl a,b-D-Gluco-pyranoside. G. Batta, K.E. Kover and J. Gervay. J. Mag. Res. Series B, 1994, 103, 185. An Unexpected Sialylation: Total Synthesis of GM4 and a Positioned Isomer. J. Gervay, J.M. Peterson, T. Oriyama, and S.J. Danishefsky. J. Org. Chem., 1993, 58, 5465. Azaglycosylation of Complex Stannyl Alkoxides with Glycal-Derived Iodosulfonamides: A Straightforward Synthesis of Sialyl-Lewis X Antigen and Other Oligosaccharide Domains. S.J. Danishefsky, K. Koseki, D.A. Griffith, J. Gervay, J.M. Peterson, F.E. McDonald and T. Oriyama. J. Am. Chem. Soc., 1992, 114, 8331. Remarkable Regioselectivity in the Chemical Glycosylation of Glycal Acceptors: A Concise Solution to the Synthesis of Sialyl-Lewis X Glycal. S.J. Danishefsky, J. Gervay, J.M.Peterson, F.E. McDonald, K. Koseki, T. Oriyama, D.A. Griffith, C.H. Wong and D.P. Dumas. J. Am. Chem. Soc., 1992, 114, 8329. A Stereospecific Route to 2-Deoxy-beta-Glycosides. J. Gervay and S.J. Danishefsky. J. Org. Chem., 1991, 56, 5448. gem-Dialkyl Effect in the Intramolecular Diels-Alder Reaction of 2-Furfuryl Methyl Fumarates: The Reactive Rotamer Effect, Enthalpic Basis for Acceleration, and Evidence for a Polar Transition State. M.E. Jung and J. Gervay. J. Am. Chem. Soc., 1991, 113, 224. A New NMR Technique for Measuring the Ground State Populations of Formate Esters: Polar Aprotic Solvents Favor the s-cis (E)-Isomer of t-Butyl Formate. M.E. Jung and J. Gervay. Tet. Lett., 1990, 31, 4685. Solvent Effects in Intramolecular Diels-Alder Reactions of 2-Furfuryl Methyl Fumarates: Evidence for a Polar Transition State. M.E. Jung and J. Gervay. J. Am. Chem. Soc., 1989, 111, 5469. Studies on the Effects of Substituents on Rate Enhancements in Intramolecular Diels-Alder Reactions: Reasons for the Gem-Dialkyl Effect. M.E. Jung and J. Gervay. Tet. Lett., 1988, 29, 2429. Patents 1. 2002 J. Gervay-Hague and M.J. Hadd Disulfone Agents and Methods of Preparing and Using Same US-Patent No. 6498277 2. 2004 J. Gervay-Hague and M.J. Hadd Disulfone Agents and Methods of Preparing and Using Same US-Patent No. 6812365 3. 2004 J. Gervay-Hague and B. Nolting Preparation and Use of Gold Glyconanoparticles US Patent Application Serial No. 10/860,390 4. 2005 J. Gervay-Hague, D.C. Meadows, T.W. North and Y.T. Duong Synthesis, Mechanistic Studies, and Anti-HIV-1 Properties of Potent Geminal Disulfone-Containing Compounds: Identification of a Coreceptor-Independent Small Molecule Inhibitor of Viral Entry US Provisional Application Serial No. 60/741,996. 5. 2005 J. Gervay-Hague, and W. Du Highly Efficient Synthesis of Alpha-O-Galactosyl Ceramides U.S. Provisional Application Serial No. 60/658,936 6. 2006 L. Ying and J. Gervay-Hague Labeled Substrate Conjugates for Identifying Enzyme Inhibitors U.S. Application Serial No. 11/190,076 7. 2006 J. Gervay-Hague, W. Du, S. DeNardo, A. Natarajan Construction of Multivalents scFv Through Alkyne-Azide 1,3-Dipolar Cycloaddition US Provisional Application Serial No. 60/785/913 Dissertations 2007, Mohamed El-Badry, Ph.D., UCD Postdoc Title: Synthetic and Physical Organic Studies of Stereoselective Glycosylation Reactions Using Glycosyl Iodides 2006, Wenjun Du, Ph.D., Postdoc, Washington Univ., St. Louis Title: Stereoselective Synthesis of α O-Galactolipids and Construction of Di-ScFv through a Trialkyne-Azide 1,3-Dipolar Cycloaddition 2006, Yan Lu, M.S. Proteolix, San Francisco, CA, Title: Synthesis of Neuraminidase Inhibitors Using Click Chemistry 2005, D. Chris Meadows, Ph.D., UCD Postdoc Title: Design, Synthesis, and Anti-HIV Activity of Geminal Disulfone-containing Compounds 2004, Laiqiang Ying, Ph.D. Molecular Probes Title: I. Synthesis of Carbohydrate-Derived Building Blocks. II. Construction of Combinatorial and Parallel Libraries. III. Development of Fluorogenic Substrates for High-throughput Screening. 2004, Jessica Wong, M.S. Title: Synthesis of Transition-State Analogs of GDP-Fucose as Glycosyl Transferase Inhibitors 2003, Son Lam, Ph.D., NIH Postdoc Title: Glycosyl Iodides: A Modern Tool for Oligosaccharide Synthesis 2001, Travis Gregar, Ph.D. 3M Title: Synthesis and Structural Characterization of Amide-Linked Neuraminic Acid Derivatives 2000, Son N. Lam, M.S. Title: Glycosylations via In Situ Formation of Glycosyl Iodides from Glycosyl Bromides 1999, Katherine D. McReynolds, Ph.D., Asst. Prof Cal State Sacramento Title: 1. Development of a Novel Elisa for the Testing of Glycobioconjugates as Anti-HIV Agents. 2. Synthesis of Potential Inhibitors of the HIV Entry Mechanism. 3. Probing the Secondary Structural Characteristics of Oligosaccharides Utilizing Circular Dichroism 1999, Denise M. Scofield, M.S. Title: Synthesis of Non-Natural Carbohydrate-Based Ligands Designed to Bind HIV Gp120 1998, Michael J. Hadd, Ph.D., Discovery Partners Title: 1. Anionic Additions to Glycosyl Iodides. 2. Neutral Addition of Alcohols to Glycosyl Iodides. 3. Glycosyl Iodides in Solid Phase Oligosaccharide Synthesis 1998, Can P. Nguyen, M.S. Title: Solution and Solid-Phase Synthesis of Sialooligomers 1997, Terrence M. Flaherty, Ph.D. Cellgate Title: 1. Synthesis of C-Glycoside Sulfones via Oxirane-Thiirane Exchange. 2. Preparation of Sialic Acid Derivatives Amenable to Solid Phase Synthesis. 3. Conformational Analysis of Complex Polysaccharides 1997, Truc N. Nguyen, M.S. Title: 1. Mechanistic Studies on the Formation of Glycosyl Iodides. 2. Synthesis of Amino Sugars via Glycosyl Iodides 1996, Abigail Parrill, Ph.D. Assoc. Prof, U. of Memphis Title: Applications of Artificial Intelligence in Drug Design 1996, Nellie N. Mamuya, M.S. Title: Synthesis and NMR Studies of Neuraminidase Inhibitors 1996, Abigail L. Parrill, M.S. Title: Supplementing Traditional Chemical Education in the World Wide Web Distinguished Appointments and Awards 2006-present Board of Editors, Organic Reactions 2003-present Associate Editor, Journal of Organic Chemistry 2003 Chair, Carbohydrates Gordon conference 2001 Vice Chair of Carbohydrates Gordon Research Conference 2001-2005 NIH, Med Chem A Study Section Member 2001-2006 Editorial Board, Journal of Carbohydrate Chemistry 2000-2006 Editorial Board, Carbohydrate Research 1999-2004 ACS, Division of Carbohydrate Chemistry Officer 1999 GenCorp 1999 Technology Achievement Award 1999 Horace Isbell Award, Carbohydrate Division of ACS 1998 Alfred P. Sloan Fellow 1997 NSF CAREER Award 1997 Eli Lilly Academic Awardee |
