Recent Kurth Group Publications

201. Nunnari, Jodi; Cassidy-Stone, Ann; Kurth, Mark. Quinazolinone derivatives and other molecules for regulating cell death, and screening methods. U.S. Pat. Appl. Publ. (2005), 45 pp.

202. Amano, Katsushi; Leung, Patrick S. C.; Rieger, Roman; Quan, Chao; Wang, Xiaobing; Marik, Jan; Suen, Yat Fan; Kurth, Mark J.; Nantz, Michael H.; Ansari, Aftab A.; Lam, Kit S.; Zeniya, Mikio; Matsuura, Eiji; Coppel, Ross L.; Gershwin, M. Eric. Chemical Xenobiotics and Mitochondrial Autoantigens in Primary Biliary Cirrhosis: Identification of Antibodies against a Common Environmental, Cosmetic, and Food Additive, 2-Octynoic Acid. Journal of Immunology (2005), 174(9), 5874-5883.

203. Dixon, Seth; Robins, Lori; Elling, Robert A.; Liu, Ruiwu; Lam, Kit S.; Wilson, David K.; Kurth, Mark J.. Discovery of selective aldo-keto reductase ligands-an on-bead assay strategy. Bioorganic & Medicinal Chemistry Letters (2005), 15(11), 2938-2942.

204. Pedemonte, Nicoletta; Sonawane, N. D.; Taddei, Alessandro; Hu, Jie; Zegarra-Moran, Olga; Suen, Yat Fan; Robins, Lori I.; Dicus, Christopher W.; Willenbring, Dan; Nantz, Michael H.; Kurth, Mark J.; Galietta, Luis J. V.; Verkman, A. S. Phenylglycine and sulfonamide correctors of defective DF508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Molecular Pharmacology (2005), 67(5), 1797-1807.

205. Yoo, Choong Leol; Fettinger, James C.; Kurth, Mark J.. Stannous chloride in alcohol: A one-pot conversion of 2-nitro-N-arylbenzamides to 2,3-dihydro-1H-quinazoline-4-ones. Journal of Organic Chemistry (2005), 70(17), 6941-6943.
 
206. Wang, Xiaobing; Dixon, Seth; Kurth, Mark J.; Lam, Kit S. Traceless solid-phase synthesis of 1,4-disubstituted-6-nitro-3,4-dihydro-1H-quinolin-2-ones. Tetrahedron Letters (2005), 46(32), 5361-5364.
 
207. Wang, Xiaobing; Dixon, Seth; Yao, Nianhuan; Kurth, Mark J.; Lam, Kit S. Microwave assisted DIC-promoted intramolecular cyclization for solid phase synthesis of trisubstituted imidazolidinones and pyrimidinones. Tetrahedron Letters (2005), 46(34), 5747-5750.

208. Suen, Yat Fan; Hope, Hkon; Nantz, Michael H.; Haddadin, Makhluf J.; Kurth, Mark J.. A Novel Route to Fully Substituted 1H-Pyrazoles. Journal of Organic Chemistry (2005), 70(21), 8468-8471.

209. Dixon, Seth; Wang, Xiaobing; Lam, Kit S.; Kurth, Mark J.. Solid-phase synthesis of quinoxaline, thiazine, and oxazine analogs through a benzyne intermediate. Tetrahedron Letters (2005), 46(43), 7443-7446.

210. Suen, Yat Fan; Robins, Lori; Yang, Baoxue; Verkman, A. S.; Nantz, Michael H.; Kurth, Mark J.. Sulfamoyl-4-oxoquinoline-3-carboxamides: Novel potentiators of defective DF508-cystic fibrosis transmembrane conductance regulator chloride channel gating. Bioorganic & Medicinal Chemistry Letters (2006), 16(3),

211. Yoo, Choong Leol; Olmstead, Marilyn M.; Tantillo, Dean J.; Kurth, Mark J.. Synthesis of 2H-pyrroles via the 1,3-dipolar cycloaddition reaction of nitrile ylides with acrylamides. Tetrahedron Letters (2006), 47(4), 477-481.

212. Liu, Yannan; Mills, Aaron D.; Kurth, Mark J.. Solid phase synthesis of 3-(5-arylpyridin-2-yl)-4-hydroxycoumarins. Tetrahedron Letters (2006), 47(12), 1985-1988.

213. Mills, Aaron D.; Nazer, Musa Z.; Haddadin, Makhluf J.; Kurth, Mark J.. N,N-Bond-Forming Heterocyclization: Synthesis of 3-Alkoxy-2H-indazoles. Journal of Organic Chemistry (2006), 71(7), 2687-2689.

214. Dixon, Seth M.; Li, Pu; Liu, Ruiwu; Wolosker, Herman; Lam, Kit S.; Kurth, Mark J.; Toney, Michael D. Slow-Binding Human Serine Racemase Inhibitors from High-Throughput Screening of Combinatorial Libraries. Journal of Medicinal Chemistry (2006), 49(8), 2388-2397.

215. Robins, Lori I.; Carpenter, Richard D.; Fettinger, James C.; Haddadin, Makhluf J.; Tinti, Dino S.; Kurth, Mark J.. Diazocinones: Synthesis and Conformational Analysis. Journal of Organic Chemistry (2006), 71(6), 2480-2485.

216. Rieger, Roman; Leung, Patrick S. C.; Jeddeloh, Melissa R.; Kurth, Mark J.; Nantz, Michael H.; Lam, Kit S.; Barsky, Daniel; Ansari, Aftab A.; Coppel, Ross L.; Mackay, Ian R.; Gershwin, M. Eric. Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis. Journal of Autoimmunity (2006), 27(1), 7-16.

217. Suen, Yat Fan; Hope, Hakon; Nantz, Michael H.; Haddadin, Makhluf J.; Kurth, Mark J.. Transannular anti-Michael addition: formation of 4H-pyrazolo[5,1-c]thiazines. Tetrahedron Letters (2006), 47(45), 7893-7896.

218. Robins, Lori I.; Dixon, Seth M.; Wilson, David K.; Kurth, Mark J.. On-bead combinatorial techniques for the identification of selective aldose reductase inhibitors. Bioorganic & Medicinal Chemistry (2006), 14(23), 7728-7735.

219. Dixon, Seth; Ziebart, Kristin T.; He, Ze; Jeddeloh, Melissa; Yoo, Choong Leol; Wang, Xiaobing; Lehman, Alan; Lam, Kit S.; Toney, Michael D.; Kurth, Mark J.. Aminodeoxychorismate Synthase Inhibitors from One-Bead One-Compound Combinatorial Libraries: "Staged" Inhibitor Design. Journal of Medicinal Chemistry (2006), 49(25), 7413-7426.

220. Carpenter, Richard D.; DeBerdt, Patrick B.; Lam, Kit S.; Kurth, Mark J.. Carbodiimide-based benzimidazole library method. Journal of Combinatorial Chemistry (2006), 8(6), 907-914.

221. Dixon, Seth M.; Milinkevich, Kristin A.; Fujii, Jeffrey; Liu, Ruiwu; Yao, Nianhuan; Lam, Kit S.; Kurth, Mark J.. A Spiroisoxazolinoproline-Based Amino Acid Scaffold for Solid Phase and One-Bead-One-Compound Library Synthesis. Journal of Combinatorial Chemistry (2007), 9(1), 143-157.

222. Mills, Aaron D.; Maloney, Patrick; Hassanein, Elsayed; Haddadin, Makhluf J.; Kurth, Mark J.. Synthesis of a library of 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides. Journal of Combinatorial Chemistry (2007), 9(1), 171-177.

223. Robins, Lori I.; Fettinger, James C.; Tinti, Dino S.; Kurth, Mark J.. Selective Nucleophilic Chemistry in the Synthesis of 5-Carbamoyl-3-sulfanylmethylisoxazole-4-carboxylic Acids. Journal of Combinatorial Chemistry (2007), 9(1), 139-142.

224. Carpenter, Richard D.; Lam, Kit S.; Kurth, Mark J.. Microwave-Mediated Heterocyclization to Benzimidazo[2,1-b]quinazolin-12(5H)-ones. Journal of Organic Chemistry (2007), 72(1), 284-287.

225. Robins, Lori I.; Kurth, Mark J.. 1,3,5-Triazine-Based Mass Spectral Tagging of One-Bead One-Compound Libraries. Organic Letters (2007), 9(2), 171-173.

226. Varela, Michael C.; Dixon, Seth M.; Price, Michael D.; Merit, Jeffrey E.; Berget, Patrick E.; Shiraki, Saori; Kurth, Mark J.; Schore, Neil E. Comparison of enantioselective reductions using bead and monolith disk' polymer formulations of CBS catalysts. Tetrahedron (2007), 63(16), 3334-3339.

227. Kirchartz, T.; Rau, U.; Kurth, M.; Mattheis, J.; Werner, J. H. Comparative study of electroluminescence from Cu(In,Ga)Se2 and Si solar cells. Thin Solid Films (2007), 515(15), 6238-6242.

228. Leung, Patrick S. C.; Park, Ogyi; Tsuneyama, Koichi; Kurth, Mark J.; Lam, Kit S.; Ansari, Aftab A.; Coppel, Ross L.; Gershwin, M. Eric. Induction of Primary Biliary Cirrhosis in Guinea Pigs following Chemical Xenobiotic Immunization. Journal of Immunology (2007), 179(4), 2651-2657.

229. Jeddeloh, Melissa R.; Holden, Jason B.; Nouri, Dustin H.; Kurth, Mark J.. A Library of 3-Aryl-4,5-dihydroisoxazole-5-carboxamides. Journal of Combinatorial Chemistry (2007), 9(6), 1041-1045.

230. Carpenter, Richard D.; Andrei, Mirela; Lau, Edmond Y.; Lightstone, Felice C.; Liu, Ruiwu; Lam, Kit S.; Kurth, Mark J.. Highly Potent, Water Soluble Benzimidazole Antagonist for Activated α4β1 Integrin. Journal of Medicinal Chemistry (2007), 50(23), 5863-5867.

231. Meng, Liping; Fettinger, James C.; Kurth, Mark J.. Intramolecular Cycloaddition of Azomethine Ylides in the Preparation of Pyrrolidino[2',3':3,4]pyrrolidino[1,2- a]benzimidazoles. Organic Letters (2007), 9(24), 5055-5058.

232. Butler, Jeffrey D.; Solano, Danielle M.; Robins, Lori I.; Haddadin, Makhluf J; Kurth, Mark J.. A Facile Synthesis of New 5 H -Indazolo[3,2- b ]benzo[ d ]-1,3-oxazines via One-Pot Intramolecular Bis-heterocyclizations. Journal of Organic Chemistry (2008), 73(1), 234-240.

233. Cassidy-Stone, Ann; Chipuk, Jerry E.; Ingerman, Elena; Song, Cheng; Yoo, Choong; Kuwana, Tomomi; Kurth, Mark J.; Shaw, Jared T.; Hinshaw, Jenny E.; Green, Douglas R.; Nunnari, Jodi. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Developmental Cell (2008), 14(2), 193-204.

234. Carpenter, Richard D.; DeBerdt, Patrick B.; Holden, Jason B.; Milinkevich, Kristin A.; Min, Taewoo; Willenbring, Dan; Fettinger, James C.; Tantillo, Dean J.; Kurth, Mark J.. Design and Synthesis of Propeller-Shaped Dispiroisoxazolinopiperidinochromanones. Journal of Combinatorial Chemistry (2008), 10(2), 225-229.

235. Carpenter, Richard D.; Andrei, Mirela; Liu, Ruiwu; Lam, Kit S.; Kurth, Mark J.. Preparation of peptide-based heterocyclic ligands for integrin imaging and therapy. PCT Int. Appl. (2008), 89pp.

236. Yoo, Choong Leol; Yu, Gui Jun; Yang, Baoxue; Robins, Lori I.; Verkman, A. S.; Kurth, Mark J.. 4'-Methyl-4,5'-bithiazole-based correctors of defective DF508-CFTR cellular processing. Bioorganic & Medicinal Chemistry Letters (2008), 18(8), 2610-2614.

237. Milinkevich, Kristin A.; Ye, Long; Kurth, Mark J.. Synthesis of 5-(Thiazol-5-yl)-4,5-dihydroisoxazoles from 3-Chloropentane-2,4-dione. Journal of Combinatorial Chemistry (2008), 10(4), 521-525.

238. Al-Nakkash, Layla; Springsteel, Mark F.; Kurth, Mark J.; Nantz, Michael H. Activation of CFTR by UCCF-029 and genistein. Bioorganic & Medicinal Chemistry Letters (2008), 18(14), 3874-3877.

239. Carpenter, Richard D.; Fettinger, James C.; Lam, Kit S.; Kurth, Mark J.. Asymmetric catalysis: resin-bound hydroxyprolylthreonine derivatives in enamine-mediated reactions. Angewandte Chemie, International Edition (2008), 47(34), 6407-6410.

240. Wakabayashi, Kanji; Lian, Zhe-Xiong; Leung, Patrick S. C.; Moritoki, Yuki; Tsuneyama, Koichi; Kurth, Mark J.; Lam, Kit S.; Yoshida, Katsunori; Yang, Guo-Xiang; Hibi, Toshifumi; Ansari, Aftab A.; Ridgway, William M.; Coppel, Ross L.; MacKay, Ian R.; Gershwin, M. Eric. Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology (Hoboken, NJ, United States) (2008), 48(2), 531-540.

241. Yu, Gui Jun; Yoo, Choong L.; Yang, Baoxue; Lodewyk, Michael W.; Meng, Liping; El-Idreesy, Tamer T.; Fettinger, James C.; Tantillo, Dean J.; Verkman, A. S.; Kurth, Mark J.. Potent s-cis-Locked Bithiazole Correctors of DF508 Cystic Fibrosis Transmembrane Conductance Regulator Cellular Processing for Cystic Fibrosis Therapy. Journal of Medicinal Chemistry (2008), 51(19), 6044-6054.

242. Schwarzer, Christian; Fischer, Horst; Kim, Eun-Jin; Barber, Katharine J.; Mills, Aaron D.; Kurth, Mark J.; Gruenert, Dieter C.; Suh, Jung H.; Machen, Terry E.; Illek, Beate. Oxidative stress caused by pyocyanin impairs CFTR Cl- transport in human bronchial epithelial cells. Free Radical Biology & Medicine (2008), 45(12), 1653-1662.

243. Choung, Wonken; Lorsbach, Beth A.; Sparks, Thomas C.; Ruiz, James M.; Kurth, Mark J.. 4-(Isoxazol-3-yl)pyrimidines from pyrimidinyl nitrile oxides. Synlett (2008), (19), 3036-3040.

245. El-Badri, M. H.; Kurth, Mark J.. Synthesis of Thiazolo- and 7,8-Dihydrothiazolo[4,5-e]benzoisoxazoles. Journal of Combinatorial Chemistry (2009), 11(2), 228-238.

246. Meng, Liping; Wang, Selina C.; Fettinger, James C.; Kurth, Mark J.; Tantillo, Dean J. Controlling selectivity for cycloadditions of nitrones and alkenes tethered by benzimidazoles: combining experiment and theory. European Journal of Organic Chemistry (2009), (10), 1578-1584.

247. Verkman, Alan; Kurth, Mark J.. Compounds having activity in increasing ion transport by mutant-cftr and uses thereof. PCT Int. Appl. (2009), 71pp.

248. Kurth, Mark J.; Verkman, Alan S. Compounds having activity in correcting mutant-cftr cellular processing and uses thereof. PCT Int. Appl. (2009), 115pp.

249. Lodewyk, Michael W.; Kurth, Mark J.; Tantillo, Dean J. Mechanisms for Formation of Diazocinones, Pyridazines, and Pyrazolines from Tetrazines-Oxyanion-Accelerated Pericyclic Cascades? Journal of Organic Chemistry (2009), 74(13), 4804-4811.

250. Oakdale, James S.; Solano, Danielle M.; Fettinger, James C.; Haddadin, Makhluf J.; Kurth, Mark J.. An Oxazolo[3,2-b]indazole Route to 1H-Indazolones. Organic Letters (2009), 11(13), 2760-2763.

251. Butler, Jeffrey D.; Donald, Michael B.; Ding, Zhensheng; Fettinger, James C.; Kurth, Mark J.. Phenylsulfonyl as a directing group for nitrile oxide cycloadditions and mCPBA epoxidations. Tetrahedron Letters (2009), 50(36), 5110-5112.