Simple Menu
Styled Menu
Next Menu

Optional Info

Sidebar image descriptionAny information can be placed in the sidebar to help your website visitors navigate your site.

To make a boxed heading like the one above, simply apply the H3 tag.

To make a box like this, assign the "sidebarlt" class.

You can do anything with a sidebar box. Insert images, ads or other web content.

Here's a text link.

To make a box like this, assign the "sidebardk" class.

You can do anything with a sidebar box. Insert images, ads or other web content.

Here's a text link.

Synthesis of medicinally important heterocycles

 

We recently completed a four-step total synthesis of the antimalarial indole alkaloid decursivine utilizing a photochemically induced cyclization cascade to provide the natural product in >50% overall yield from commercially available starting materials. This powerful method opens access to concise synthetic pathways to extracyclic indole alkaloids and we are exploring its application to a range of other natural products of medicinal interest.

 

   

 

Lead references:

 

"Concise Photochemical Synthesis of the Antimalarial Indole Alkaloid Decursivine."M. Mascal, K. Modes, A. Durmus, Angewandte Chem. Int. Ed. 2011, 50, 4445.

 

"The Vinylogous Witkop Cyclization." E. L. Ruchkina, A. J. Blake, M. Mascal Tetrahedron Lett. 1999, 40, 8443.

 

 

Website templates by JustDreamweaver.com