An increased understanding of system properties underlying cellular networks enables us to construct novel systems by assembling the components and the control systems into new combinations. We are applying this approach to the field of metabolic engineering, which strives for the optimization of desired properties and functions, such as the production of valuable biochemicals. The production of valuable chemicals from microorganisms suites to solve some significant challenges, such as converting renewable feedstocks into energy-rich biofuels. Currently, our main focus is developing synthetic organisms capable of converting CO₂ directly to biofuels.