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The main theme of our research program is the application of synthetic organic chemistry to the study of molecular assemblies, medicinal chemistry, green chemistry, and fundamental aspects of molecular structure. Current work is focused in six main areas: (1) the chemical conversion of biomass into organic molecules of interest as fuels and value-added products (2) concise natural product synthesis (3) the design and synthesis of topologically interesting organic molecules (4) the design and synthesis of novel cyclophane-based host-guest systems (5) the design and synthesis of novel self-organizing molecular systems (6) ab initio modeling of unconventional modes of noncovalent boding